Thursday, 14th June 2018


07:30 to 8:30  Registration
08:30 to 8:40  Welcome
by Georg Duda
08:40 to 10:40 Understanding and supporting endogenous bone regeneration
Chaired by Klaus-Dieter Schaser und Claudia Schlundt 
08:40 Bone fractures from an evolutionary perspective (15’+5’)
Nadja Fröbisch
09:00 Strategies to enhance musculoskeletal regeneration (15’+5’)
Dietmar W. Hutmacher
09:20 Mechanical strain and BMP2-stimulation – An unexpected crosstalk? (15’+5’)
Petra Knaus
09:40 Think bone – A story on bone formation (15’+5’)
Michael Amling
10:00 From chromatin folding to shaping bones (15’+5’)
Stefan Mundlos
10:20 Tendon: A neglected tissue in musculoskeletal research (15’+5’)
Britt Wildemann
10:40 to 11:10  Coffee break
11:10 to 12:50 The role of inflammation in musculoskeletal regeneration
Chaired by Hans-Dieter Volk and Christian H. Bucher
11:10 The puzzling role of inflammation on bone healing and regeneration (15’+5’)
Franz Jakob
11:30 Analysis of osteo-immune crosstalk during bone healing by longitudinal intravital imaging (15’+5’)
Anja Hauser and Raluca Niesner
11:50 The role of tissue resident cells in homeostasis and regeneration (15’+5’)
Andreas Diefenbach
12:10 The future of cartilage regeneration (15’+5’)
Henning Madry
12:30 Bone healing and aging – The role of the adaptive immune system for regeneration (15’+5’)
Katharina Schmidt-Bleek
12:50 to 13:50 Lunch break
13:50 to 15:10 Role of metabolic constrains in musculoskeletal regeneration
Chaired by Gerhard Schmidmaier and Julia Löffler
13:50 Mechano-dependency of vessel formation and its role in regeneration (15’+5’)
Holger Gerhardt
14:10 Metabolomics – An essential feature to understand bone healing? (15’+5’)
Stefan Kempa
14:30 White and Brown – Essentials in bone maintenance and regeneration? (15’+5’)
Tim J. Schulz
14:50 Understanding the impact of traumatic brain injury on fracture healing – The holy grail to improved regeneration? (15’+5’)
Johannes Keller
15:10 to 15:40 Coffee break
15:40 to 17:20 Restoring functional capacity and mobility – The ultimate goal of musculoskeletal regeneration
Chaired by Thomas Mittlmeier and Alison Agres
15:40 Human movement and musculoskeletal loading conditions to aid clinical decision making (15’+5’)
William R. Taylor
16:00 Internal loading conditions during activities of daily living, an essential prerequisite for the treatment of injury and disease (15’+5’)
Markus Heller
16:20 Musculoskeletal adaptation due to mechanical stimuli (15’+5’)
Sara Checa
16:40 Talking the talk versus walking the walk – Challenges and opportunities on paths to medical technology translation (15’+5’)
David Grainger
17:00 Bone regeneration and spinal function (15’+5’)
Hendrik Schmidt
17:20 to 17:50 Coffee break
17:50 to 18:50 Official ceremony to celebrate 10 years Julius Wolff Institute
Chaired by Carsten Perka and Michael Schütz
17:50 Welcome from the Chancellery (10′)
Helge Braun, Head of the Chancellor’s Office
18:00 Welcome from the Charité (10’)
Axel Radlach Pries, Dean of the Charité
18:10 A historic view on Julius Wolff as surgeon and scientist (10′)
Georg Bergmann
18:20 The future of musculoskeletal surgery and research at the Charité (10’)
Norbert Haas
18:30 The Future of musculoskeletal research at the Julius Wolff Institute (10’)
Georg Duda
18:40 Welcome by Julius Wolff’s decendant (10′)
Katherine Wolff (great-granddaughter of Julius Wolff)
19:30 to 23:00 Boat tour with reception and dinner buffet (invited guests only)
Address: Reichstagufer 18, 10117 Berlin

Friday, 15th June 2018

09:00 to 11:20 Biomaterials in musculoskeletal regeneration
Chaired by Viola Vogel and Aline Lückgen
09:00 Engineered human bone/bone marrow for in vitro biocompatibility testing of implant materials (15’+5’)
Janosch Schoon
09:20 Restoring mobility meets the surgeon’s capability – Challenges and pitfalls in joint replacement (15’+5’)
Michael Morlock
09:40 Advanced therapeutics: Innovative biomaterial approaches in tissue regeneration (15’+5’)
Carsten Werner
10:00 Multifunctional biomaterials to modulate the behaviour of progenitor cells and to enhance skeletal muscle regeneration (15’+5’)
Sven Geißler
10:20 Resorbable metals – Implant revolution or unrealistic vision (15’+5’)
Frank Witte
10:40 Biomaterial architecture opens new routes for bone defect regeneration (15’+5’)
Ansgar Petersen
11:00 Patterned alginate hydrogels to guide cell response and tissue formation (15’+5)
Amaia Cipitria
11:20 to 11:45 Coffee break
11:45 to 13:25 Enhancing musculoskeletal regeneration processes in compromised scenarios
Chaired by Michael Raschke and Andreas Radbruch
11:45 Trap for dendritic cells – Learning from cancer to enhance regeneration (15’+5’)
David Mooney
12:05 Adult stem/stromal cells to support chronic ischemia and muscle regeneration (15+5’)
Tobias Winkler
12:25 Advanced cell therapies: Remaining preclinical and clinical challenges (15’+5’)
Dirk Strunk
12:45 Current challenges and future opportunities in treatment of periprosthetic joint infection (15’+5’)
Andrej Trampuz
13:05 Why does hierarchical organization matter in regeneration? (15’+5’)
Peter Fratzl
13:25 to 14:10 Lunch break
14:10 to 16:10 Mechanobiology
Chaired by Adamantios Arampatzis and Clemens Kühn
14:10 Imaging Wolff’s Law (15’+5’)
Ralph Müller
14:30 Cartilage and mechano-biology – The unintended alliance (15’+5’)
Thomas Pap
14:50 Muscle adaptation and regeneration – Going beyond the limits (15’+5’)
Walter Herzog
15:10 The sensor to Wolff’s Law – The osteocyte (15’+5’)
Jenneke Klein-Nulend
15:30 Bone adaptation across ages – Lessons to learn in skeletal mechanobiology (15’+5’)
Bettina Willie
15:50 Mechanobiology: Spatial confinement down regulates the pro-inflammatory response of macrophages (15’+5’)
Viola Vogel
16:10 to 16:25 Coffee break
16:25 to 17:20 Panel discussion – What is necessary for translational research? (55’)
Chaired by David Grainger and Elliott Gruskin
Participants in the panel: Petra Reinke, Britt Wildemann, Michael Raschke and Dietmar W. Hutmacher

18:00 to 20:00 Closing event: Museum of Natural History – Official tour plus visit of the bone cellar (invited guests only)
Address: Invalidenstraße 43, 10115 Berlin